Hier finden Sie eine sicher unvollständige Auflistung von wissenschaftlichen Granatapfel Studien:

Abd El Wahab SM, EI Fiki NM, Mostafa SF, Hassan AEB: Characterization of certain steroid hormones in Punica granatum L seeds. Bull. Fac. Pharm. (Cairo University). 1998 Adams LS,

SeeramNP, AggarwalBB,Takada Y, Sand D, Heber D: Pomegranate juice, total pomegranate ellagitannins, and pu­nicalagin suppress inflammatory Gell si­gnaling in colon cancer cells. Journal of Agricultural and Food Chemistry. 2006

Afaq F, Malik A, Syed D, Maes D, Matsui MS, Mukhtar H: Pomegranate freit extract modulates UV-B-mediated phosphoryla­tion of mitogen activated protein kinases and activation of nuclear factor kappaB in normal human epidermal keratinocytes Paragraph sign. Photochemistry and Pho­tobiology. 2005

Afaq F, Saleem M, Krueger CG, Reed JD, Mukhtar H: Anthocyanin- and hydroly­zable tannin-rich pomegranate freit ex­tract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice. International Journal of Cancer. 2005

Ahmed S, Wang N, Hafeez BB, Cheruvu VK, Haqqi TM: Punica granatum L extract in­hibits IL-7beta-induced expression of matrix metalloproteinases by inhibiting the activation of MAP kinases and NF­kappaB in human chondrocytes in vitro. Journal of Nutrition. 2005

Albrecht M et al.: Pomegranate extracts potently suppress Proliferation, xenograft growth, and Invasion of human prostate cancer cells. Journal of Medicinal Food. 2004

j Ajaikumar KB, Asheef M, Babu BH, Padik­kala J: The inhibition of gastric mucosal injury by Punica granatum L (pomegra­nate) methanolic extract. Journal of Eth­nopharmacology. 2005

Aviram M et al.: Pomegranate juice con­sumption reduces oxidative stress, athe­rogenic modifications to LDL, and platelet aggregation: Studien in humans and in atherosclerotic apolipoprotein E-deficient mice. American Journal of Clinical Nutri­tion. 2000

Aviram M: Pomegranate juice consump­tion for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blond Pressure and LDL oxidation. Clinical Nutrition. 2004

Azadzoi KM, Schuluran RN, Aviram M, Si­roky MB: Oxidative stress in arteriogenic erectile dysfunction: prophylactic rote of antioxidants. Journal of Urology. 2005

Azmi AS, Bhat SH, Hanif S, Hadi SM: Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for anticancer properties. FEBS Lett. 2006

Boukef K, Souissi HR, Balansard G: Con­tribution to the study of plants used in traditional medicine in . Plant Me­dicine and Phytotherapy. 1982

Brewer GJ et al.: Treatment of metastasic cancer with tetrathiomolybdate, an anti- , copper, antiangiogenic agent: Phase 1 Study. Clinc. Cancer Res. 2000

Caceres, A, Giron LM, Alvarado SR, Torres MF: Screening of antimicrobial activity of plants popularly used in for the treatment of dermatomucosal diseases. Journal of Ethnopharmacology. 1987

Cerda B, Ceron J], Tomas-Barberan FA, Espin JC: Repeated oral administration of high dosen of the pomegranate ellagitan­nin punicalagin to rats for 37 days is not toxic. J Agric Food Chem. 2003; Cerda B, Espin JC, Parra S, Martinez ß To­mas-Barberan FA: The potent in vitro an­tioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopy­ran-6-one derivatives by the colonic mi­croflora of healthy humans. European Journal of Nutrition. 2004

Choi DW: Identiflcation of steroid hor­mones in pomegranate (Punica granatum) using HPLC and GC-mass spectrometry. Food Chemistry. 2006

Coates RJ, Weiss NS, Daling JR, Rettmer RL, Warnick GR Cancer risk in relation to Se­rum copper levels. Cancer Res. 1989

Cunningham KS, Gotlieb Al: The rote of shear stress in the pathogenesis of ather­osclerosis. Laborstory lnvestigation. 2005

Czyz J, Madeja Z, Irmer U, Korohoda W, Hulser DF: Flavonoid apigenin inhibits motility and invasiveness of carcinoma cells in vitro. International Journal of Cancer. 2005

Dai Q Borenstein AR, Wu Y, Jackson JC, Larson EB: Freit and vegetable Juices and Alzheimer's disease: the Kaure Project. Am J Med. 2006

De Nigris F et al.: Effects of a pomegranate freit extract rieh in punicalagin an oxida­tion-sensitive genes and eNOS activity at sites of perturbed shear stress and athe­rogenesis. Cardiovasc Res. 2007

De Nigris F et al.: Beneficial effects of po­megranate juice an oxidation-sensitive genes and endothelial nitric oxide syn­thase activity at sites of perturbed shear stress. Proceedings of the National Aca­demy of Sciences . 2005

De Nigris F, Williams-Ignarro S, Botti C, Sica V, Ignarro LJ, Napoli C: Pomegranate juice reduces oxidized low-density lipoprotein downregulation of endothelial nitric oxide synthase in human coronary endothelial cells. Nitric Oxide. 2006

Esmaillzadeh A, Tahbaz F, Gaieni 1, Alavi­Majd H, Azadbakht L: Cholesterol-lowe­ring effect of concentrated pomegranate juice consumption in type II diabetic pa­tients with hyperlipidemia. Int J Vitam Nutr Res. 2006

Fang M, Chen D, Yang CS: Dietary poly­phenols may affect DNA methylation. J Nutr. 2007

Farkas D: Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450-3A activity: comparison with gra­pefruit juice. Pharmacol. 2007

Folkman J: Anti-angiogenesis: new con­cept for therapy of solid tumors. Annals of Surgery. 1972

Forest CP, Padma-Nathan H, Liker HR: Ef­ficacy and safety of pomegranate juice an improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, pla­cebo-controlled, double-blind, crossover study. Res. 2007

Fuhrman B, Volkova N, Aviram M: Pome­granate juice inhibits oxidized LDL uptake and cholesterol biosynthesis in macro­phages. J Nutr Biochem. 2005

Gaig P, Botey J, Gutierrez V, Pena M, Ese­verri J4 Marin A: Allergy to pomegranate (Punica granatum). J Investig Allergol Clin Immunol. 1992

Gaig P, Bartolome B, Lleonart R, Garcia­Ortega P, Palacios R, Richart C: Allergy to pomegranate (Punica granatum). Allergy. 1999

Gil Ml, Tomas-Barberan FA, Hess-Pierce B, Holcroft DM, Kader AA: Antioxidant ac­tivity of pomegranate juice and its rela­tionship with phenolic composition and processing. Journal of Agricultural and Food Chemistry. 2000

Girolami A, Agostino D, Cliffton EE: The effect of ellagic acid an coagulation in vivo. Blood. 1966

Gujral ML, Varma DR, Sareen KN: Oral contraceptives . Part 1. Preliminary ob­servations an the antifertility effect of some indigenous drugs. Indian Journal of Medical Research. 1960

Hadi SM, Bhat SH, Azmi AS, Hanif S, Sha­mim U, Uliah MF: Oxidative breakage of cellular DNA by plant polyphenols: A pu­tative mechanism for anticancer proper­ties. Semin Cancer. Biol. 2007

Harturan RE et al.: Pomegranate juice de­creases amyloid load and improves be­havior in a mouse model of Alzheimer's disease. Neurobiol Dis. 2006

Hidaka M et al.: Effects of pomegranate juice an human cytochrome p450 3A (CYP3A) and carbamazepine pharmaco­kinetics in rats. Drug Metab Dispos. 2005

J Hora JJ, Maydew ER, Lansky EP, Dwivedi C: Chemopreventive effects of pomegranate seed oil an skin tumordevelopment in CDl mice. Journal of Medicinal Food. 2003

Hong SJ, Kim 51, Kwon SM, Lee JR, Chung BC: Comparative study of concentration of isoflavones and lignans in Plasma and prostatic tissues of normal control and benign prostatic hyperplasia. Yonsei Med J. 2002

Huang TH et al.: Pomegranate flower im­proves cardiac lipid metabolism in a dia­betic rat modelt role of lowering circula­ting lipids. British Journal
of Pharmacolo­gy. 2005

Huang TH et al.: Anti-diabetic schon of Punica granatum flowerextract: activation of PPAR-gamma and identification of an active component. Toxicology and Applied Pharmacology. 2005

Huang TH et al.: Pomegranate flower ex­tract diminishes cardiac fibrosis in Zucker diabetic fatty rats: modulation of cardiac endothelin-1 and clear factor-kappaB pathways. Journal of Cardiovascular Pharmacology. 2005

ang YT, Lee LT, Lee PP, Lin YS, Lee MT: Targeting of focal adhesion krosse by fla­noids and Small-interfering RNAs re­duces tumor cell migration ability. Anti­cancer Research. 2005

J Igea JM et al.: Adverse reaction to pome­granate ingestion. Allergy. 1991

Ignarro LJ, Byrns RE, Sumi D, de Nigris F, Napoli C: Pomegranate juice protects nitric oxide against oxidative destruction and enhances the biological actions of nitric oxide. Nitric Oxide. Epub 2006 Jochle W: Biology and pathology of re­production in Greek mythology. Contra­ception. 1971

Jung KH et aL: Suppressive effect of Punica granatum an the production of tumor necrosis factor(Tnf) in BV2 microglial cells. Biological and Pharmaceutical Bulletin. 2006.

Kaplan M et al.: Pomegranate juice sup­plementation to atherosclerotic mice re­duces macrophage lipid peroxidation, cellular cholesterol accumulation and de­velopment of atherosclerosis. J Nutr. 2001

KaurG,JabbarZ,AtharM,AlamMS:Punica granatum (pomegranate) flower extract possesses potent antioxidant activity and abrogates Fe-NTA induced hepatotoxicity in mice. Food and Chernical Toxicology. 2006

Kawaii S, Lansky EP: Differentiation-pro­moting activity of pomegranate (Punica granatum) fruit extracts in HL-60 human promyelocytic leukemia cells. Journal of Medicinal Food. 2004

Kennedy T et al.: Copper-dependent in­flammation and nuclear factor-KB activa­tion by particulate air pollution. American journal of respiratory cell and molecular biology. 1998

Khan N, Hadi N, Afaq F, Syed DN, Kweon MH, Mukhtar H: Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice. Carcinoge­nesis. 2007

Khan N, Afaq F, Kweon MH, Kim K, Mukhtar H. Oral consumption of pome­granate fruit extract inhibits growth and progression of primary lung tumors in mice. Cancer Res. 2007

Kirn ND et al.: Chemopreventive and ad­juvant therapeutic potential of pomegra­nate (Punica granatum) for human breast cancer. Breast Cancer Research and Treatment. 2002

Kirn H, Yoon YJ, Shon JH, Cha IJ, Shin JG, Liu KH: Inhibitory effects of fruit juices an CYP3A activity. Drug Metab Dispos. 2006

Kohno H, Suzuki R, Yasui Y, Hosokawa M, Miyashita K, Tanaka T: Pomegranate seed oil rich in conjugated linolenic acid sup­presses chemically induced colon carci­nogenesis in rats. Cancer Science. 2004

Lad V, Frawley D: The Yoga of Herbs, SantaFe, NM: Lotus Press; 1986

Lansky EP et al.: Possible synergistic pro­state cancer suppression by anatomically discrete pomegranate fractions. Investi­gational New Drugs. 2005

Lansky EP, Harrison G, Froorn P, Jiang WG: Pomegranate (Punica granatum) pure chemicals show possible synergistic inhi­bition of human PC-3 prostate cancer cell invasion across Matrigel. Investigational New Drugs. 2005

Lansky EP, Newman RA: Punica granatum (pomegranate) and its potential for pre­vention and treatment of inFlammation and cancer. J Ethnopharmacol. 2007

Lansky EP: Beware of pomegranates be­aring40 % ellagic acid. Med Food.2006

Larrosa M, Tomas-Barberan FA, Espin JC: The dietary hydrolysable tannin punica­lagin releases ellagic acid that induces apoptosis in human colon adenocarcino­ma Caco-2 cells by using the mitochondrial pathway. The Journal of Nutritional Bio­chemistry. 2005 Larrosa M, Gonzalez-Sarrias A, Garcia­Conesa MT, Tomas-Barberan FA, Espin JC:Urolithins, ellagic acid-derived metaboli­tes produced by human colonic microflora, exhibit estrogenic and antiestrogenic ac­tivities. J Agric Food Chem. 2006

Levin GM: Pomegranate (Punica grana­tum) plant genetic resources in . Plant Genetic Resources Newslet­ter.1994

Li Yet al.: Punica granatum flower extract, a potent alpha-glucosidase inhibitor, im­proves postprandial hyperglycemia in Zucker diabetic fatty rats. J Ethnophar­macol. 2005

Liu RH: Potential synergy of phytochemi­cals in cancer prevention: mechanism of action. J Nutr. 2004

Loren DJ, Seeram NP, Schulman RN, Hol­tzman DM: Maternal dietary supplemen­tation with pomegranate juice is neuro­protective in an animal model of neonatal hypoxic-ischemic brain injury. Pediatric Research. 2005

Lowndes SA, Harris AL: The role of copper in tumour angiogenesis. J Mammary Gland Biol Neoplasia. 2005

Malik A, Afaq F, Sarfaraz S, Adhami VM, Syed DN, Mukhtar H: Pomegranate fruit juice for chemoprevention and chemo­therapy of prostate cancer. Proceedings of the National Academy of Sciences . 2005

Malik A, Azam S, Hadi N, Hadi SM: DNA degradation by water extract of green tea in the presence of copper ions: implicati­ons for anticancer properties. Phytother Res. 2003

Manach C, Williamson G, Morand C, Scal­bert A, Remesy C: Bioavailability and bio­efficacy of polyphenols in humans. 1. Re­view of 97 bioavailability studies. AmJ Clin Nutr. 2005

Manach C, Scalbert A, Morand C, Remesy C, Jimenez L: Polyphenols: food sources and bioavailability. Am J Clin Nutr. 2004

Maubach J et al.: Quantitation of soy-de­rived phytoestrogens in human breast tissue and biological fluids by high-per­formance liquid chromatography. J Chro­matogr B Anal Technol Biomed Life Sci. 2003

Mehta R, Lansky EP: Breast cancer che­mopreventive properties of pomegranate (Punica granatum) fruit extracts in a mouse mammary organ culture. European Journal of Cancer Prevention. 2004

Milner JA: Nutrition and Gene Regulation, Molecular Targets for Bioactive Food Components. The Journal of Nutrition. 2004

Milner JA: Diet and Cancer: Facts and Controversies. Nutrition and Cancer. 2006

Moskaug J0. Carlsen H, Myhrstad MC, Blomhoff R: Polyphenols and glutathione synthesis regulation. Am J Clin Nutr. 2005

Mori-Okamoto J, Otawara-Hamamoto Y, Yamato H, Yoshimura H: Pomegranate extract improves a depressive state and bone properties in menopausal syndrome model ovariectomized mice. Journal of Ethnopharmacology. 2004

Nagaraju N, Rao KN: A survey of plant crude drugs of Rayalaseema, Andhra Pra­desh, . Journal of Ethnopharmacolo­gy.1990

Nayak Shivananda B, Bhat Vinutha R, Upadhyay Dinesh, Udupa Saraswati L: Copper and ceruloplasmin status in serum of prostate and colon cancer patients. In­dian Journal of Physiology and Pharma­cology. 2003

Neurath AR, Strick N, Li YY, Debnath AK: Punica granatum (Pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide. BMC Infect. Dis. Oct. 2004

Neurath AR, Strick N, Li YY, Debnath AK: Punica granatum (pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide. Ann NY Acad Sci. 2005

Pantuck AJ et al.: Phase 11 Study of Pome­granate Juice forMen with Rising Prostate­Specific Antigen following Surgery or Ra­diation for Prostate Cancer. Clin Cancer Res. 2006

Persichini T, Percario Z, Mazzon E, Cola­santi M, Cuzzocrea S, Musci G: Copper activates the NT-kappaB pathway in vivo. Antioxid Redox Signal. 2006 Polagruto JA, Schramm DD, Wang-Pola­gruto JF, Lee L, Keen CL: Effects of flavo­noid-rich beverages an prostacyclin syn­thesis in humans and human aortic en­dothelial cells: association with ex vivo platelet function. Journal of Medicinal Food. 2003

Reddy MK, Gupta SK, Jacob MR Khan Sl, Ferreira D: Antioxidant, Antimalarial and Antimicrobial Activities of Tannin-Rich Fractions, Ellagitannins and Phenolic Acids from Punica granatum L Planta Med. 2007

Rosenblat M, Hayek T, Aviram M: Anti­oxidative effects of pomegranate juice (PJ) consumption by diabetic patients an se­rum and an macrophages. Atherosclerosis. 2006

Rozenberg 0, Howell A, Aviram M: Po­megranate juice sugar fraction reduces macrophage oxidative state, whereas white grape juice sugar fraction increases it. Atherosclerosis. 2006

Saxena A, Vikram NK: Role of selected Indian plants in management of type 2 diabetes: a review. Journal of Alternative and Complementary Medicine. 2004

Schubert SY, Lansky EP, Neeman 1: Antio­xidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavonoids. J Ethnophar­maco1.1999

Schubert SY, Neeman 1, Resnick N: A novel mechanism for the inhibition of NF-kap­paB activation in vascular endothelial cells by natural antioxidants. The Federation of American Societies for Experimental Bio­logy Journal. 2002

Seeram NP, Lee R, Heber D: Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from po­megranate (Punica granatum L) juice. Clin Chim Acta. 2004

Seeram NP et al.: In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total po­megranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. Journal of Nutritional Biochemistry. 2005

Seeram NP, Schulman RN, Heber D:. Po­megranates: Ancient Roots to Modern Medicine. Boca Raton, Florida, : Taylor and Francis CRC Press; 2006.

Settheetham W. Ishida T: Study of geno­toxic effects of antidiarrheal medicinal herbs an human cells in vitro. The Sou­theast Asian Journal of Tropical Medicine and Public Heatth. 1995